Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558843 | 0.84 | TSHR (0.32) | TSHRHTTHSD17B10MGAMGAA | |
| SCHEMBL575208 | 0.77 | SMN1; SMN2 (0.38) | TSHRHTTSMN1; SMN2 | |
| SCHEMBL10012851 | 0.76 | TSHR (0.56) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL10010047 | 0.76 | TSHR (0.42) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL171078 | 0.76 | POLB (0.37) | TSHRHTTHSD17B10MGAMGAA | |
| SCHEMBL816653 | 0.74 | TSHR (0.40) | TSHRHTTHSD17B10MGAMGAA | |
| SCHEMBL23722714 | 0.73 | HTT (0.34) | TSHRHTTSMN1; SMN2 | |
| SCHEMBL575246 | 0.73 | SMN1; SMN2 (0.34) | TSHRHTTSMN1; SMN2 | |
| SCHEMBL575244 | 0.73 | SMN1; SMN2 (0.34) | TSHRHTTSMN1; SMN2 | |
| SCHEMBL15951726 | 0.73 | TSHR (0.41) | TSHRHTTHSD17B10MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968736-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | University of Pittsburgh—of the Commonwelth Systems of Higher Education (US) | 2011-06-28 | — | — | US | disclosed |
| EP-1765073-A4 | ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIV PITTSBURGH (US) | 2009-07-15 | — | — | EP | disclosed |
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | PITTSBURGH UNIVERSITY OF - OF THE COMMONWEALTH SYSTEM OF HIGHER | 2009-02-05 | — | — | US | disclosed |
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-07 | — | — | US | disclosed |
| US-7321046-B2 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1765073-A2 | ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060270862-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | PITTSBURGH, UNIVERSITY OF | 2006-11-30 | — | — | US | disclosed |
| US-7122686-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2006-10-17 | — | — | US | disclosed |
| US-20060025395-A1 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | PITTSBURGH, UNIVERSITY OF | 2006-02-02 | — | — | US | disclosed |
| WO-2005117588-A2 | ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20040186165-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-23 | — | — | US | disclosed |
| WO-2004022552-A1 | ANALOGS OF DISCODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2004-03-18 | — | — | WO | disclosed |
| WO-2003080567-A2 | INTERMEDIATES FOR THE SYNTHESIS OF DISCODERMOLIDE AND RELATED ANALOGUES AND METHODS FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-10-02 | — | — | WO | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | RRS1, RPS3A, RPS3 | TSHR 274/4885HTT 3504/4885HSD17B10 1640/4885 |
| US-20080188651-A1 | Analogs of dictyostatin, intermediates therefor and methods of systhesis thereof | RPS14, RPL41, DHCR7 | TSHR 332/4885HTT 2574/4885HSD17B10 1386/4885 |
| US-20060270862-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | RRS1, RPS6KA3, RPS6KA4 | TSHR 386/4885HTT 4162/4885HSD17B10 1353/4885 |
| US-20060025395-A1 | Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof | DCXR, DHCR7, RRM2B | TSHR 165/4885HTT 2580/4885HSD17B10 945/4885 |
| US-20040186165-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | DECR1, RRS1, WEE1 | TSHR 290/4885HTT 3877/4885HSD17B10 1528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.