Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.35 |
| ▸ | CDK8 | P49336 | 7/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.33 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.32 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16610738 | 0.66 | KDM4E (0.37) | CCNCCDK8PROKR1 | |
| SCHEMBL17514145 | 0.64 | CCNC (0.66) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL17514105 | 0.64 | CCNC (0.66) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL19349733 | 0.64 | CCNC (0.66) | CCNCCDK8DRD2GSK3ACDK9 | |
| SCHEMBL16611122 | 0.63 | PDE2A (0.39) | CCNCCDK8PROKR1 | |
| SCHEMBL16610696 | 0.63 | PDE2A (0.37) | CCNCCDK8PROKR1 | |
| SCHEMBL22327707 | 0.63 | CCNA2 (0.43) | — | |
| SCHEMBL22327913 | 0.61 | IGF1R (0.47) | — | |
| SCHEMBL23064464 | 0.61 | LMNA (0.49) | — | |
| SCHEMBL22327956 | 0.60 | IGF1R (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183239-A1 | INDAZOLES | Merck Patent GmbH (DE) | 2017-06-28 | — | — | EP | disclosed |
| WO-2016026549-A1 | INDAZOLES | MERCK PATENT GMBH (DE) | 2016-02-25 | — | — | WO | disclosed |