Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 7/20 | 0.36 |
| ▸ | CDK8 | P49336 | 7/20 | 0.36 |
| ▸ | PRLHR | P49683 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16610696 | 0.85 | PDE2A (0.37) | PDE2APROKR1CCNCCDK8 | |
| SCHEMBL28004266 | 0.81 | PDE2A (0.41) | PDE2APROKR1CCNCCDK8 | |
| SCHEMBL16754705 | 0.80 | PDE2A (0.42) | PDE2A | |
| SCHEMBL16610770 | 0.77 | KDR (0.35) | PDE2ACCNCCDK8 | |
| SCHEMBL16610738 | 0.77 | KDM4E (0.37) | PDE2APROKR1CCNCCDK8 | |
| SCHEMBL28003812 | 0.74 | KDM4E (0.40) | PDE2APROKR1CCNCCDK8 | |
| SCHEMBL16610496 | 0.70 | PDE2A (0.40) | PDE2A | |
| SCHEMBL28004257 | 0.68 | CYP11B2 (0.37) | PDE2APROKR1CCNCCDK8 | |
| SCHEMBL16610525 | 0.67 | CYP19A1 (0.40) | PDE2A | |
| SCHEMBL23551030 | 0.66 | PDE2A (0.39) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143722-A1 | SUBSTITUTED PYRROLIDINES AS ROS TYROSINE KINASE INHIBITORS | NIPPON SHINYAKU CO., LTD. (JP) | 2017-05-25 | — | — | US | disclosed |
| US-9580413-B2 | Substituted pyrrolidines as ROS tyrosine kinase inhibitors | NIPPON SHINYAKU CO., LTD. (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20150152095-A1 | AROMATIC HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL | NIPPON SHINYAKU CO., LTD. (JP) | 2015-06-04 | — | — | US | disclosed |
| EP-2857398-A1 | AROMATIC HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL | Nippon Shinyaku Co., Ltd. (JP) | 2015-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152095-A1 | AROMATIC HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL | HRH4, CYP3A4, CYP3A5 | PDE2A 1208/4885PROKR1 708/4885CCNC 4579/4885 |
| US-20170143722-A1 | SUBSTITUTED PYRROLIDINES AS ROS TYROSINE KINASE INHIBITORS | ROS1, NOX4, NOX3 | PDE2A 1397/4885PROKR1 407/4885CCNC 3648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.