SCHEMBL17514902

SCHEMBL17514902

Fc1cc(Cl)ccc1-c1cc(Cl)c[c]c1Cl

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.38
KMO O15229 2/20 0.36
GRM2 Q14416 4/20 0.36
EGLN2 Q96KS0 1/20 0.36
PPOX P50336 1/20 0.34
AHR P35869 1/20 0.34
HSD11B1 P28845 1/20 0.33
CLK1 P49759 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.32
PDK2 Q15119 1/20 0.32
PPARG P37231 1/20 0.31
PPARA Q07869 1/20 0.31
BCHE P06276 1/20 0.31
AKR1C3 P42330 1/20 0.30
AKR1C2 P52895 1/20 0.30
APP P05067 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17514891 0.89 KMO (0.35) S100A4KMOGRM2EGLN2HSD11B1
SCHEMBL30598347 0.81 S100A4 (0.46) S100A4KMOGRM2EGLN2PPOX
SCHEMBL23638850 0.81 S100A4 (0.46) S100A4KMOGRM2EGLN2PPOX
SCHEMBL1274816 0.80 AHR (0.50) S100A4PPOXAHRHSD11B1
SCHEMBL434747 0.78 GRM2 (0.38) S100A4KMOGRM2EGLN2HSD11B1
SCHEMBL3410408 0.78 TP53 (0.42) S100A4PPOXAHR
SCHEMBL17514979 0.76 NISCH (0.39) GRM2AHRHSD11B1CLK1
SCHEMBL17515034 0.76 KMO (0.36) S100A4KMOGRM2EGLN2HSD11B1
SCHEMBL17514893 0.76 KMO (0.36) S100A4KMOGRM2EGLN2HSD11B1
SCHEMBL17514905 0.74 KMO (0.35) S100A4KMOGRM2EGLN2AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016026830-A1 NOVEL FUNGICIDAL PYRAZOLE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-02-25 WO disclosed