Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 11/20 | 0.43 |
| ▸ | GABRD | O14764 | 11/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 11/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 11/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 11/20 | 0.43 |
| ▸ | GABRE | P78334 | 11/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 11/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 11/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 11/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751541 | 1.00 | GABRP (0.43) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1752588 | 0.88 | GABRP (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1752589 | 0.88 | GABRP (0.41) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1752246 | 0.80 | GABRB3 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1752247 | 0.80 | GABRB3 (0.39) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1751938 | 0.78 | GABRB3 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1751939 | 0.78 | GABRB3 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1752468 | 0.77 | GABRP (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1752469 | 0.77 | GABRP (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4979425 | 0.77 | GABRP (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968584-B2 | Substituted arylpyrazoles | PFIZER INC. (US) | 2011-06-28 | — | — | US | disclosed |
| EP-1893581-B1 | SUBSTITUTED ARYLPYRAZOLES FOR USE AGAINST PARASITITES | PFIZER LTD (GB) | 2010-01-27 | — | — | EP | disclosed |
| US-20090186924-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER INC. (US) | 2009-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186924-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP3A4, CYP3A43, CYP4B1 | GABRP 575/4885GABRD 888/4885GABRA1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.