Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17524625 | 0.81 | GABRR1 (0.38) | — | |
| SCHEMBL14497823 | 0.79 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2GFPT1 | |
| SCHEMBL13540707 | 0.78 | GRIK1 (0.37) | — | |
| SCHEMBL15909791 | 0.78 | GRIK1 (0.37) | — | |
| SCHEMBL14852861 | 0.78 | GRIK1 (0.37) | — | |
| SCHEMBL17920045 | 0.78 | GRIK1 (0.37) | — | |
| SCHEMBL1709871 | 0.78 | GRIK1 (0.37) | — | |
| SCHEMBL28020839 | 0.75 | HCAR2 (0.50) | HCAR2KEAP1NFE2L2GFPT1 | |
| SCHEMBL26759885 | 0.75 | HCAR2 (0.41) | HCAR2KEAP1NFE2L2GFPT1 | |
| SCHEMBL27976502 | 0.74 | HCAR2 (0.44) | HCAR2KEAP1NFE2L2GFPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266927-B2 | Cyclosporin A analogs | ALLERGAN, INC. (US) | 2016-02-23 | — | — | US | disclosed |
| US-20160039880-A1 | CYCLOSPORIN A ANALOGS | ALLERGAN, INC. | 2016-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039880-A1 | CYCLOSPORIN A ANALOGS | TSLP, CHP1, PPP3R1 | HCAR2 1159/4885KEAP1 3746/4885NFE2L2 4033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.