PPP3R1

Calcineurin subunit B type 1 · P63098 · PPP3R1 on Sugi Atlas →

2,429 patent compounds predicted against PPP3R1, 2,316 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cyclosporine (SCHEMBL3490)	1.00	1/20
Cyclosporine (SCHEMBL3491)	1.00	1/20
Cyclosporine (SCHEMBL4442)	1.00	1/20
Cyclosporine (SCHEMBL4443)	1.00	1/20
Cyclosporine (SCHEMBL17555)	1.00	1/20
Cyclosporine (SCHEMBL66895)	1.00	1/20
Cyclosporine (SCHEMBL211370)	1.00	1/20
Cyclosporine (SCHEMBL1708909)	1.00	1/20
Cyclosporine (SCHEMBL1708949)	1.00	1/20
Cyclosporine (SCHEMBL4331439)	1.00	1/20
Cyclosporine (SCHEMBL4454089)	1.00	1/20
Cyclosporine (SCHEMBL12522443)	1.00	1/20
Cyclosporine (SCHEMBL12799543)	1.00	1/20
Cyclosporine (SCHEMBL12923645)	1.00	1/20
Cyclosporine (SCHEMBL13073066)	1.00	1/20
Cyclosporine (SCHEMBL13223210)	1.00	1/20
Cyclosporine (SCHEMBL13379284)	1.00	1/20
Cyclosporine (SCHEMBL13509209)	1.00	1/20
Cyclosporine (SCHEMBL13987071)	1.00	1/20
Cyclosporine (SCHEMBL14099239)	1.00	1/20

Clinical trials — most relevant to PPP3R1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Ketamine Treatment Effects on Synaptic Plasticity in Depression	PHASE4	COMPLETED
Tacrolimus Treatment for Refractory Autoimmune Cytopenia	PHASE4	UNKNOWN
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD	PHASE3	COMPLETED
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision	PHASE3	COMPLETED
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome	PHASE3	COMPLETED
Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer	PHASE2	COMPLETED
Cyclosporine For The Treatment Of COVID-19(+)	PHASE2	COMPLETED
Everolimus (RAD001) Therapy for Epilepsy in Patients With Tuberous Sclerosis Complex (TSC)	PHASE1/PHASE2	COMPLETED
Bioequivalence Study of Tacrolimus in Healthy Volunteers	PHASE1	COMPLETED
Evaluating MED2005 & Nitrostat Bioavailability	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects	PHASE1	COMPLETED
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors	PHASE1	WITHDRAWN
Immune Signature of Palmoplantar Pustulosis	nan	COMPLETED
The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes	nan	RECRUITING
Studying Phosphorus Metabolism	nan	COMPLETED
Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome	nan	UNKNOWN
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13)	nan	NOT_YET_RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Genetic Predictors of Lithium Response in Bipolar Disorder	nan	COMPLETED
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms	nan	COMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Cardiovascular Effects of Empagliflozine	nan	UNKNOWN
Identification of Novel Targetable Kinases in SR-a GvHD	nan	COMPLETED
Brain Involvement in Dystrophinopathies Part 2	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Is T-lymphocyte Calcineurin Phosphatase Up-regulated by Treatment With Tacrolimus?	nan	COMPLETED
Relationship of Gestational Age and Urine Concentration of S100B in Preterm and Term Infants in the First Week of Life	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PPP3R1 binder may also engage these)

Protein	Name	Similarity
P63099	—	1.000	P63099 →
Q24214	—	1.000	Q24214 →
P63100	—	1.000	P63100 →
Q63810	—	1.000	Q63810 →
P48451	—	1.000	P48451 →
G5EDN6	—	0.997	G5EDN6 →
P0CM55	—	0.996	P0CM55 →
Q6FLU4	—	0.994	Q6FLU4 →
P42322	—	0.994	P42322 →
Q2TBI5	—	0.993	Q2TBI5 →
Q63811	—	0.993	Q63811 →
P28470	—	0.992	P28470 →
P25296	—	0.991	P25296 →
Q96LZ3	—	0.990	Q96LZ3 →
P87072	—	0.989	P87072 →
P0CM54	—	0.989	P0CM54 →
Q757B7	—	0.989	Q757B7 →
Q55G87	—	0.988	Q55G87 →
Q6CGE6	—	0.988	Q6CGE6 →
Q6BWS8	—	0.987	Q6BWS8 →
Q9UU93	—	0.986	Q9UU93 →
Q874T7	—	0.985	Q874T7 →
P79880	—	0.984	P79880 →
P43080	—	0.983	P43080 →
O73761	—	0.983	O73761 →
P51177	—	0.982	P51177 →
P35243	—	0.982	P35243 →
P34057	—	0.982	P34057 →
Q5ZM44	—	0.982	Q5ZM44 →
A0A2H0ZYD3	—	0.981	A0A2H0ZYD3 →