SCHEMBL175183

SCHEMBL175183

CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(-c3ccccc3)c(C(=O)c3ccccc3)s2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 1.00
RORB Q92753 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL175300 0.94 RORC (0.89) RORCRORB
SCHEMBL175371 0.93 RORC (1.00) RORCRORB
SCHEMBL175486 0.93 RORC (0.93) RORCRORB
SCHEMBL175194 0.93 RORC (0.86) RORCRORB
SCHEMBL175493 0.93 RORC (1.00) RORCRORB
SCHEMBL175661 0.92 RORC (0.84) RORCRORB
SCHEMBL174203 0.91 RORC (0.83) RORCRORB
SCHEMBL174561 0.91 RORC (0.92) RORCRORB
SCHEMBL174641 0.91 RORC (1.00) RORCRORB
SCHEMBL175258 0.91 RORC (0.83) RORCRORB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160317473-A1 METHODS OF TREATING OR PREVENTING BRAIN DAMAGE DUE TO HYPOXIC-ISCHEMIA CHILDREN'S HEALTHCARE OF ATLANTA, INC. 2016-11-03 US disclosed
WO-2012100734-A1 COMPOUNDS USEFUL AS RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS GLAXO GROUP LIMITED (GB) 2012-08-02 WO disclosed
WO-2012028100-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 WO disclosed
WO-2012028100-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 WO disclosed