SCHEMBL1752200 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	PTGS2	P35354	2/20	0.41

▸	PPARG	P37231	1/20	0.38

▸	NPC1	O15118	1/20	0.38

▸	RAB9A	P51151	1/20	0.38

▸	PDE4D	Q08499	11/20	0.37

▸	PDE4B	Q07343	11/20	0.37

▸	PDE4A	P27815	10/20	0.37

▸	PDE4C	Q08493	10/20	0.37

▸	PYGL	P06737	1/20	0.35

▸	MAPK1	P28482	1/20	0.34

▸	HTT	P42858	1/20	0.34

▸	TDP1	Q9NUW8	1/20	0.34

▸	L3MBTL1	Q9Y468	1/20	0.34

▸	LMNA	P02545	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1752198	1.00	PTGS2 (0.41)	PTGS2PPARGNPC1RAB9APDE4D
SCHEMBL1751225	0.94	PTGS2 (0.41)	PTGS2PPARGNPC1RAB9APDE4D
SCHEMBL1751223	0.94	PTGS2 (0.41)	PTGS2PPARGNPC1RAB9APDE4D
SCHEMBL1750793	0.82	PDE4D (0.36)	PTGS2PPARGPDE4DPDE4BPDE4A
SCHEMBL1750791	0.82	PDE4D (0.36)	PTGS2PPARGPDE4DPDE4BPDE4A
SCHEMBL1750790	0.82	PDE4D (0.36)	PTGS2PPARGPDE4DPDE4BPDE4A
SCHEMBL3655199	0.79	PDE4D (0.39)	PTGS2PPARGPDE4DPDE4BPDE4A
SCHEMBL1750624	0.78	PDE4D (0.50)	PDE4DPDE4BPDE4APDE4C
SCHEMBL4033314	0.78	PDE4D (0.59)	PTGS2PDE4DPDE4BPDE4APDE4C
SCHEMBL1750895	0.75	HTT (0.43)	PTGS2NPC1RAB9APYGLMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7968724-B2	Ester derivatives as phosphodiesterase inhibitors	CHIESI FARMACEUTICI S.P.A. (IT)	2011-06-28	—	—	US	claimed