Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 12/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.39 |
| ▸ | PDE4A | P27815 | 11/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661646 | 0.85 | PDE4D (0.36) | PDE4DPDE4BPDE4APDE4CPTGS2 | |
| SCHEMBL1751223 | 0.82 | PTGS2 (0.41) | PDE4DPDE4BPDE4APDE4CPTGS2 | |
| SCHEMBL1751225 | 0.82 | PTGS2 (0.41) | PDE4DPDE4BPDE4APDE4CPTGS2 | |
| SCHEMBL4033314 | 0.80 | PDE4D (0.59) | PDE4DPDE4BPDE4APDE4CPTGS2 | |
| SCHEMBL1750624 | 0.80 | PDE4D (0.50) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1752200 | 0.79 | PTGS2 (0.41) | PDE4DPDE4BPDE4APDE4CPTGS2 | |
| SCHEMBL1752198 | 0.79 | PTGS2 (0.41) | PDE4DPDE4BPDE4APDE4CPTGS2 | |
| SCHEMBL1750895 | 0.77 | HTT (0.43) | PTGS2MAPK1HTTTDP1L3MBTL1 | |
| SCHEMBL1751525 | 0.76 | ALDH1A1 (0.48) | PTGS2MAPK1HTTTDP1L3MBTL1 | |
| SCHEMBL6526531 | 0.76 | PDE4D (0.55) | PDE4DPDE4BPDE4APDE4CPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225205-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2010-09-08 | — | — | EP | claimed |
| WO-2009077068-A9 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2009-08-20 | — | — | WO | claimed |
| WO-2009077068-A1 | ESTER DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-06-25 | — | — | WO | claimed |