⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685204 | 0.91 | ADRA2A (0.34) | — | |
| SCHEMBL617496 | 0.85 | — | — | |
| SCHEMBL6692977 | 0.80 | OPRD1 (0.41) | — | |
| SCHEMBL290880 | 0.80 | — | — | |
| SCHEMBL3970107 | 0.80 | OPRD1 (0.41) | — | |
| SCHEMBL327601 | 0.80 | OPRD1 (0.41) | — | |
| Bromide SCHEMBL7969410 | 0.77 | OPRD1 (0.40) | — | |
| SCHEMBL1489209 | 0.75 | — | — | |
| SCHEMBL4957978 | 0.75 | — | — | |
| SCHEMBL88222 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 403 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125376-A1 | FUSED BICYCLIC HETEROARYL AMIDE COMPOUND AS PROTEIN AGGREGATION INHIBITOR | 上海京新生物医药有限公司 | 2023-07-06 | — | — | WO | claimed |
| CN-108929268-B | Chiral 1,2-diamine compound and synthetic method thereof | 中国科学院上海有机化学研究所 | 2022-10-04 | — | — | CN | claimed |
| EP-3154941-B1 | SMALL MOLECULE LFA-1 INHIBITORS | ALLOCYTE PHARMACEUTICALS AG (CH) | 2021-01-20 | — | — | EP | claimed |
| EP-3558971-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2019-10-30 | — | — | EP | claimed |
| US-20190040008-A1 | SMALL MOLECULE LFA-1 INHIBITORS | ALLOCYTE PHARMACEUTICALS AG (CH) | 2019-02-07 | — | — | US | claimed |
| US-10077238-B2 | Small molecule LFA-1 inhibitors | ALLOCYTE PHARMACEUTICALS AG (CH) | 2018-09-18 | — | — | US | claimed |
| WO-2018119208-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | WO | claimed |
| US-20170121284-A1 | SMALL MOLECULE LFA-1 INHIBITORS | ALLOCYTE PHARMACEUTICALS AG (CH) | 2017-05-04 | — | — | US | claimed |
| EP-2909193-B1 | PHENYL LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-19 | — | — | EP | claimed |
| EP-3154941-A1 | SMALL MOLECULE LFA-1 INHIBITORS | AlloCyte Pharmaceuticals AG (CH) | 2017-04-19 | — | — | EP | claimed |
| CN-1212695-A | 4-amino pyrimidine derivates, medicament containing these compounds, their use | THOMAE GMBH DR K (DE) | 1999-03-31 | — | — | CN | claimed |
| US-5500435-A | BENZIMIDAZOLES AND BENZOTRIAZOLES, TREATMENT OF RETINOID SENSITIVE SKIN DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1996-03-19 | — | — | US | claimed |
| EP-0366884-B1 | Novel vinyl-terminated carbamylmethylated melamines, vinyl-terminated polyurethane/polyamide polymers and coating/adhesive compositions containing same | CYTEC TECH CORP (US) | 1996-01-03 | — | — | EP | claimed |
| US-5420147-A | Benzimidazoles, benzotriazoles, controlling metabolism of retinoids, skin cancer | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-05-30 | — | — | US | claimed |
| US-5157046-A | Systemic or topical application of substituted benzimidazole or benzotriazole which suppresses retinoid metabolism | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-10-20 | — | — | US | claimed |
| US-5066656-A | Aromatase inhibitor, prevention of biosynthesis of estrogens, treatment of estrogen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-11-19 | — | — | US | claimed |
| EP-0371559-A2 | Use of benzimidazoles in the treatment of epithelial disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-06 | — | — | EP | claimed |
| US-4866136-A | 4-AMINOPIPERIDINE MODIFIED POLYANHYDRIDE | PENNWALT CORPORATION (US) | 1989-09-12 | — | — | US | claimed |
| US-4618599-A | WATER SOLUBILITY | RHONE-POULENC SANTE (FR) | 1986-10-21 | — | — | US | claimed |
| EP-0079740-B1 | ANTHRANILOYLOXYALKANOATES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1985-11-13 | — | — | EP | claimed |