Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14772134 | 0.90 | GRM2 (0.33) | GRM2DRD2HTR2AHRH1 | |
| SCHEMBL14765109 | 0.85 | MEN1 (0.33) | DRD2HTR2AHRH1 | |
| SCHEMBL14765043 | 0.80 | MAPK1 (0.36) | SMN1; SMN2LMNAKDM4EUSP2MAPK1 | |
| SCHEMBL21013664 | 0.69 | SMN1; SMN2 (0.33) | SMN1; SMN2KDM4EGLAUSP2MAPK1 | |
| SCHEMBL9286625 | 0.56 | AR (0.42) | GRM2LMNAKDM4EGLAHSD17B10 | |
| SCHEMBL9281425 | 0.55 | PSEN1 (0.39) | GRM2LMNAKDM4EGLAHSD17B10 | |
| SCHEMBL5559755 | 0.54 | SIRT1 (0.37) | — | |
| SCHEMBL14763878 | 0.54 | MEN1 (0.32) | — | |
| SCHEMBL19605722 | 0.53 | GRM2 (0.43) | GRM2SMN1; SMN2KDM4EGLAHSD17B10 | |
| SCHEMBL11823485 | 0.53 | AADAT (0.45) | SMN1; SMN2LMNAKDM4EUSP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9265773-B2 | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases | MERCK SHARP & DOHME CORP. (US) | 2016-02-23 | — | — | US | disclosed |