Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | SDCBP | O00560 | 1/20 | 0.42 |
| ▸ | SDC2 | P34741 | 1/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290250 | 0.78 | BRD4 (0.56) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL30833835 | 0.78 | METAP1 (0.47) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL17179269 | 0.78 | METAP1 (0.43) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL27172637 | 0.78 | METAP1 (0.47) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL7601380 | 0.75 | NPC1 (0.50) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL1029578 | 0.74 | HSD17B3 (0.49) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL30336648 | 0.74 | SDCBP (0.42) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL2144912 | 0.74 | SDCBP (0.48) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL1500062 | 0.74 | MAOA (0.46) | METAP1PARP10TDP2PARP11SDCBP | |
| SCHEMBL1500134 | 0.74 | SDCBP (0.42) | METAP1PARP10TDP2PARP11SDCBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111057048-B | Aminopyrazine/pyridine compound, preparation method and application | 上海凌达生物医药有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2016197114-A1 | TANK-BINDING KINASE-1 PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2016-12-08 | — | — | WO | disclosed |
| EP-2985285-A1 | ESTROGEN-RELATED RECEPTOR ALPHA BASED PROTAC COMPOUNDS AND ASSOCIATED METHODS OF USE | Yale University (US) | 2016-02-17 | — | — | EP | disclosed |