Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.64 |
| ▸ | ESRRG | P62508 | 10/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | PGR | P06401 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | GBA1 | P04062 | 1/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.63 |
| ▸ | PRKCG | P05129 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17523663 | 0.89 | CYP19A1 (0.55) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17505999 | 0.85 | PTGS2 (0.51) | ESR1ESRRGNPC1RAB9ALMNA | |
| SCHEMBL19181333 | 0.85 | PTGS2 (0.51) | ESR1ESRRGNPC1RAB9ALMNA | |
| SCHEMBL17523669 | 0.84 | ESRRB (0.65) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17523668 | 0.84 | ESR1 (0.61) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17523645 | 0.82 | ESR1 (0.62) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17523674 | 0.82 | ESR1 (0.62) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17524237 | 0.81 | ESR1 (0.58) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17524185 | 0.81 | ESR1 (0.58) | ESR1ESR2ESRRGMAPTHTR6 | |
| SCHEMBL17523646 | 0.81 | ESR1 (0.60) | ESR1ESR2ESRRGMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | THE PENN STATE RESEARCH FOUNDATION | 2017-08-03 | — | — | US | disclosed |
| WO-2016022325-A1 | NOVEL TRIARYLETHYLENE COMPOUNDS AND METHODS USING SAME | THE PENN STATE RESEARCH FOUNDATION (US) | 2016-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217914-A1 | Novel Triarylethylene Compounds and Methods Using Same | CYP46A1, GSTA2, GSTA1 | ESR1 1247/4885ESR2 642/4885ESRRG 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.