Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 1.00 |
| ▸ | RAB9A | P51151 | 15/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 0.79 |
| ▸ | BLVRB | P30043 | 1/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.63 |
| ▸ | RELA | Q04206 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29842481 | 1.00 | NPC1 (1.00) | NPC1RAB9AMAOABLVRBHDAC6 | |
| Ataluren SCHEMBL29361641 | 0.88 | MAOA (1.00) | NPC1RAB9AMAOABLVRBHDAC6 | |
| Ataluren SCHEMBL60614 | 0.88 | MAOA (1.00) | NPC1RAB9AMAOABLVRBHDAC6 | |
| Ataluren SCHEMBL29360108 | 0.88 | MAOA (1.00) | NPC1RAB9AMAOABLVRBHDAC6 | |
| Ataluren SCHEMBL29365205 | 0.88 | MAOA (1.00) | NPC1RAB9AMAOABLVRBHDAC6 | |
| Ataluren SCHEMBL59167 | 0.87 | MAOA (0.97) | NPC1RAB9AMAOABLVRBHDAC6 | |
| SCHEMBL1752210 | 0.87 | MAOA (0.79) | NPC1RAB9AMAOABLVRBHDAC6 | |
| Ataluren SCHEMBL59165 | 0.87 | MAOA (0.97) | NPC1RAB9AMAOABLVRBHDAC6 | |
| SCHEMBL17946207 | 0.87 | MAOA (0.79) | NPC1RAB9AMAOABLVRBHDAC6 | |
| SCHEMBL12171232 | 0.87 | NPC1 (0.77) | NPC1RAB9AMAOABLVRBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115141120-A | Electrooxidation preparation method of astallurens | 湖南大学 | 2022-10-04 | — | — | CN | disclosed |
| US-9273076-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273076-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273076-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20140235586-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235586-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20140235586-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-8710031-B2 | Compounds for nonsense suppression and methods for their use | PTC THERAPEUTICS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710031-B2 | Compounds for nonsense suppression and methods for their use | PTC THERAPEUTICS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-8710031-B2 | Compounds for nonsense suppression and methods for their use | PTC THERAPEUTICS, INC. (US) | 2014-04-29 | — | — | US | disclosed |
| US-20110160164-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC (US) | 2011-06-30 | — | — | US | disclosed |
| US-20110160164-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC (US) | 2011-06-30 | — | — | US | disclosed |
| US-7902235-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902235-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-7902235-B2 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090203752-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090203752-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20090203752-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| EP-1799659-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044682-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC THERAPEUTICS, INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235586-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | NSUN2, UPF1, NSUN3 | NPC1 732/4885RAB9A 2618/4885MAOA 3716/4885 |
| US-20090203752-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | NSUN2, UPF1, NSUN3 | NPC1 732/4885RAB9A 2618/4885MAOA 3716/4885 |
| US-20110160164-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION AND METHODS FOR THEIR USE | NSUN2, UPF1, NSUN3 | NPC1 786/4885RAB9A 2707/4885MAOA 3396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.