Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 10/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21359095 | 0.84 | F2 (0.42) | F2SMN1; SMN2ERCC5FEN1LMNA | |
| SCHEMBL28156288 | 0.77 | LMNA (0.49) | SMN1; SMN2ERCC5FEN1LMNAALDH1A1 | |
| SCHEMBL18381559 | 0.76 | — | — | |
| SCHEMBL29677851 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4000697 | 0.76 | F2 (0.44) | F2SMN1; SMN2ERCC5FEN1ALDH1A1 | |
| SCHEMBL18571382 | 0.75 | HDAC6 (0.42) | LOXL2 | |
| SCHEMBL5875847 | 0.75 | LOXL2 (0.36) | SMN1; SMN2LOXL2LOXPSEN1PSEN2 | |
| SCHEMBL21408966 | 0.74 | CYP1A2 (0.41) | SMN1; SMN2LOXL2LOX | |
| SCHEMBL22323374 | 0.73 | F2 (0.42) | F2SMN1; SMN2ERCC5FEN1LMNA | |
| SCHEMBL18381918 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016020295-A1 | OPTIONALLY FUSED HETEROCYCLYL-SUBSTITUTED DERIVATIVES OF PYRIMIDINE USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGIC AND AUTOIMMUNE DISEASES | NUEVOLUTION A/S (DK) | 2016-02-11 | — | — | WO | disclosed |