Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235485 | 0.84 | GRM4 (0.38) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL13535278 | 0.83 | TRPV1 (0.39) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL10459336 | 0.79 | CDK2 (0.35) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10459320 | 0.78 | ALDH1A1 (0.37) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10459366 | 0.77 | PRKCA (0.40) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10458860 | 0.77 | CCNK (0.46) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10458859 | 0.77 | POLB (0.34) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10459475 | 0.77 | SSTR4 (0.33) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10458838 | 0.77 | CDK2 (0.35) | CDK2CCNT1CCNKCCNE1CDK9 | |
| SCHEMBL10458864 | 0.77 | PRKCQ (0.42) | CDK2CCNT1CCNKCCNE1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318408-B1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMA (US) | 2016-02-17 | — | — | EP | disclosed |