Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 2/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.34 |
| ▸ | GBA1 | P04062 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13732233 | 0.79 | LOX (0.38) | LOXEPAS1GBA1PTGS2PTGS1 | |
| SCHEMBL13730937 | 0.78 | LOX (0.36) | LOXEPAS1GBA1PTGS2PTGS1 | |
| SCHEMBL30807872 | 0.77 | GBA1 (0.41) | LOXEPAS1GBA1PTGS2PTGS1 | |
| SCHEMBL13732234 | 0.76 | GBA1 (0.38) | LOXEPAS1GBA1PTGS2PTGS1 | |
| SCHEMBL13732377 | 0.75 | GCK (0.40) | LOXEPAS1PTGS2PTGS1 | |
| SCHEMBL17530476 | 0.73 | EPAS1 (0.33) | LOXEPAS1GBA1PTGS2PTGS1 | |
| SCHEMBL31668233 | 0.72 | LOX (0.35) | LOXEPAS1PTGS2PTGS1NR1H2 | |
| SCHEMBL27823143 | 0.70 | PTGS2 (0.44) | EPAS1PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL13731126 | 0.69 | LOX (0.33) | LOXEPAS1GBA1PTGS2PTGS1 | |
| SCHEMBL13731094 | 0.69 | LOX (0.39) | LOXEPAS1GBA1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699543-B1 | NOVEL MODULATORS OF CORTICAL DOPAMINERGIC- AND NMDA-RECEPTOR-MEDIATED GLUTAMATERGIC NEUROTRANSMISSION | INTEGRATIVE RES LAB SWEDEN AB (SE) | 2016-03-02 | — | — | EP | claimed |