Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464080 | 0.85 | LMNA (0.37) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL2997423 | 0.81 | LMNA (0.38) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL2469793 | 0.81 | LMNA (0.40) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL1936858 | 0.76 | LMNA (0.42) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL2997871 | 0.75 | BRAF (0.42) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL15941967 | 0.73 | CYP19A1 (0.47) | KMT2A | |
| SCHEMBL12164724 | 0.73 | KEAP1 (0.38) | ALDH1A1LMNAEGFRCSNK1D | |
| SCHEMBL2432818 | 0.73 | KEAP1 (0.41) | PDE10ACSNK1D | |
| SCHEMBL15941908 | 0.72 | CYP19A1 (0.47) | — | |
| SCHEMBL1936885 | 0.70 | CYP19A1 (0.40) | ALDH1A1LMNAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331502-B1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL MYERS SQUIBB CO (US) | 2016-03-02 | — | — | EP | disclosed |