SCHEMBL17530902

SCHEMBL17530902

[CH2]COCCOc1ccn(-c2ccc(Cl)c(Cl)c2)n1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 20/20 0.66
KCNH2 Q12809 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL729173 0.86 SIGMAR1 (0.68) SIGMAR1KCNH2
SCHEMBL731151 0.82 SIGMAR1 (0.67) SIGMAR1KCNH2
SCHEMBL728820 0.80 SIGMAR1 (1.00) SIGMAR1KCNH2
SCHEMBL5309319 0.79 SIGMAR1 (0.70) SIGMAR1KCNH2
SCHEMBL728818 0.78 SIGMAR1 (0.88) SIGMAR1KCNH2
SCHEMBL466979 0.78 SIGMAR1 (0.88) SIGMAR1KCNH2
Hydrochloric Acid SCHEMBL1903312 0.77 SIGMAR1 (0.86) SIGMAR1KCNH2
SCHEMBL467006 0.77 SIGMAR1 (1.00) SIGMAR1KCNH2
Hydrochloric Acid SCHEMBL1899101 0.76 SIGMAR1 (0.98) SIGMAR1KCNH2
SCHEMBL467105 0.76 SIGMAR1 (1.00) SIGMAR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1996580-B1 PYRRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS ESTEVE LABOR DR (ES) 2016-03-02 EP claimed