Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17530902 | 0.86 | SIGMAR1 (0.66) | SIGMAR1KCNH2 | |
| SCHEMBL731151 | 0.81 | SIGMAR1 (0.67) | SIGMAR1KCNH2 | |
| SCHEMBL728820 | 0.81 | SIGMAR1 (1.00) | SIGMAR1KCNH2 | |
| SCHEMBL466979 | 0.80 | SIGMAR1 (0.88) | SIGMAR1KCNH2 | |
| SCHEMBL728818 | 0.79 | SIGMAR1 (0.88) | SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL1903312 | 0.79 | SIGMAR1 (0.86) | SIGMAR1KCNH2 | |
| SCHEMBL5309319 | 0.78 | SIGMAR1 (0.70) | SIGMAR1KCNH2 | |
| SCHEMBL467023 | 0.77 | SIGMAR1 (1.00) | SIGMAR1KCNH2 | |
| SCHEMBL31432743 | 0.76 | SIGMAR1 (0.60) | SIGMAR1KCNH2 | |
| SCHEMBL467006 | 0.76 | SIGMAR1 (1.00) | SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996580-B1 | PYRRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| US-8138186-B2 | Pyrazole derivatives as sigma receptors antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-03-20 | — | — | US | disclosed |
| US-8138186-B2 | Pyrazole derivatives as sigma receptors antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-03-20 | — | — | US | disclosed |
| US-8138186-B2 | Pyrazole derivatives as sigma receptors antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-03-20 | — | — | US | disclosed |
| US-20090227589-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-09-10 | — | — | US | disclosed |
| US-20090227589-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-09-10 | — | — | US | disclosed |
| US-20090227589-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2009-09-10 | — | — | US | disclosed |
| EP-1996580-A2 | PYRRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | Laboratorios del Dr. Esteve S.A. (ES) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007098964-A2 | PYRRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007098964-A2 | PYRRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2007-09-07 | — | — | WO | disclosed |
| EP-1829873-A1 | Pyrrazole derivatives as sigma receptors antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-05 | — | — | EP | disclosed |
| EP-1829873-A1 | Pyrrazole derivatives as sigma receptors antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227589-A1 | PYRAZOLE DERIVATIVES AS SIGMA RECEPTORS ANTAGONISTS | SIGMAR1, TMEM97, P2RX3 | SIGMAR1 1/4885KCNH2 1001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.