Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14928472 | 0.93 | TSHR (0.42) | TSHRALDH1A1CYP3A4RECQLMAPK1 | |
| SCHEMBL15365471 | 0.86 | PPIA (0.41) | TSHRALDH1A1CYP3A4RECQLMAPK1 | |
| SCHEMBL1425442 | 0.85 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4MAPK1VCAM1 | |
| SCHEMBL12658937 | 0.85 | PDK1 (0.45) | TSHRALDH1A1CYP3A4MAPK1VCAM1 | |
| SCHEMBL12396038 | 0.82 | TSHR (0.46) | TSHRALDH1A1CYP3A4RECQLSMN1; SMN2 | |
| SCHEMBL29804082 | 0.82 | TSHR (0.48) | TSHRALDH1A1CYP3A4RECQLMAPK1 | |
| SCHEMBL3175084 | 0.82 | TSHR (0.48) | TSHRALDH1A1CYP3A4RECQLMAPK1 | |
| SCHEMBL7786706 | 0.81 | ALDH1A1 (0.50) | TSHRALDH1A1CYP3A4MAPK1VCAM1 | |
| SCHEMBL80032 | 0.80 | PPIA (0.47) | TSHRALDH1A1CYP3A4RECQLMAPK1 | |
| SCHEMBL29586844 | 0.80 | PPIA (0.47) | TSHRALDH1A1CYP3A4RECQLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016026937-A1 | NEW SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-25 | — | — | WO | disclosed |