Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20339408 | 0.88 | LMNA (0.49) | LMNAMAPTGAAJAK2MCHR1 | |
| SCHEMBL9697377 | 0.88 | LMNA (0.49) | LMNAMAPTGAAJAK2MCHR1 | |
| SCHEMBL3787607 | 0.86 | MCHR1 (0.47) | LMNAMAPTGAANPC1RAB9A | |
| SCHEMBL1066091 | 0.85 | TSHR (0.45) | LMNAMAPTGAAJAK2NPC1 | |
| Methyl Alcohol SCHEMBL11789519 | 0.83 | TSHR (0.43) | LMNAMAPTGAAJAK2NPC1 | |
| SCHEMBL1052278 | 0.82 | LMNA (0.54) | LMNAMAPTGAAJAK2MCHR1 | |
| SCHEMBL15473216 | 0.81 | ALDH1A1 (0.54) | GAANPC1RAB9ATSHRMCHR1 | |
| 1-Hydroxy-2-Propoxybenzene SCHEMBL1805086 | 0.80 | GAA (0.72) | LMNAMAPTGAAJAK2NPC1 | |
| SCHEMBL16957909 | 0.79 | HTR1B (0.43) | LMNAMAPTGAANPC1RAB9A | |
| SCHEMBL1837129 | 0.79 | LMNA (0.49) | LMNAMAPTGAAJAK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160060260-A1 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060260-A1 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060260-A1 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-03-03 | — | — | US | disclosed |
| WO-2016033416-A1 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2016-03-03 | — | — | WO | disclosed |
| WO-2016033416-A1 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2016-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060260-A1 | BROMODOMAIN INHIBITORS FOR TREATING DISEASE | BRDT, BRPF3, BRWD1 | LMNA 2533/4885MAPT 1371/4885GAA 1704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.