Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.58 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14796578 | 0.79 | METAP2 (0.62) | PARP1DAOCHEK1METAP2GRIN2D | |
| SCHEMBL30273114 | 0.79 | METAP2 (0.62) | PARP1DAOCHEK1METAP2GRIN2D | |
| SCHEMBL10134606 | 0.77 | PARP1 (0.79) | PARP1FEN1ACHEDAOCSNK2A1 | |
| SCHEMBL30866440 | 0.76 | PARP1 (0.57) | PARP1FEN1ACHEDAOCHEK1 | |
| SCHEMBL30766035 | 0.76 | PARP1 (0.62) | PARP1FEN1ACHEDAOCHEK1 | |
| SCHEMBL30866441 | 0.76 | PARP1 (0.57) | PARP1FEN1ACHEDAOCHEK1 | |
| SCHEMBL30704720 | 0.74 | PARP1 (1.00) | PARP1FEN1ACHECHEK1CSNK2A1 | |
| SCHEMBL1478179 | 0.74 | PARP1 (1.00) | PARP1FEN1ACHECHEK1CSNK2A1 | |
| SCHEMBL9533317 | 0.73 | PARP1 (0.62) | PARP1FEN1ACHEDAOCHEK1 | |
| SCHEMBL2411557 | 0.72 | AURKA (0.60) | PARP1FEN1DAOXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856257-B2 | Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2) | SANOFI (FR) | 2018-01-02 | — | — | US | disclosed |
| EP-2978764-B1 | PYRAZOLONAPHTHYRIDINONE DERIVATIVES AS METAP2 INHIBITORS (METHIONINE AMINOPEPTIDASE TYPE-2) | SANOFI SA (FR) | 2017-04-19 | — | — | EP | disclosed |
| US-20160060265-A1 | PYRAZOLONAPHTHYRIDINONE DERIVATIVES AS METAP2 INHIBITORS (METHIONINE AMINOPEPTIDASE TYPE-2) | SANOFI (FR) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060265-A1 | PYRAZOLONAPHTHYRIDINONE DERIVATIVES AS METAP2 INHIBITORS (METHIONINE AMINOPEPTIDASE TYPE-2) | METAP2, METAP1, XPNPEP2 | PARP1 2711/4885FEN1 785/4885ACHE 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.