Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17540247 | 0.87 | KMT2A (0.45) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL17545650 | 0.86 | KMT2A (0.44) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL17540234 | 0.86 | KMT2A (0.44) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL17540199 | 0.85 | EPHX2 (0.42) | KMT2AMEN1HDAC3HDAC1HDAC6 | |
| SCHEMBL19440808 | 0.84 | KMT2A (0.54) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL19440806 | 0.84 | KMT2A (0.51) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL19440833 | 0.84 | KMT2A (0.53) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL19440822 | 0.82 | KMT2A (0.51) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL19440814 | 0.81 | KMT2A (0.51) | KMT2AMEN1L3MBTL1MAPTUSP2 | |
| SCHEMBL19440853 | 0.81 | KMT2A (0.52) | KMT2AMEN1L3MBTL1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505729-B2 | Isoxazole analogs as mediators of transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2016-11-29 | — | — | US | disclosed |
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | VANDERBILT UNIVERSITY | 2016-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052896-A1 | ISOXAZOLE ANALOGS AS MEDIATORS OF TRANSCRIPTIONAL INDUCTION OF E-CADHERIN | CDH1, VIM, EPCAM | KMT2A 3375/4885MEN1 3924/4885L3MBTL1 3823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.