Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176338 | 0.90 | DGAT1 (0.53) | DGAT1CNR1CDK5KDRFLT3 | |
| SCHEMBL174942 | 0.89 | DGAT1 (0.48) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL178117 | 0.89 | EPHX2 (0.45) | DGAT1NAMPTKDRFLT3 | |
| SCHEMBL15021930 | 0.86 | DGAT1 (0.47) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL176236 | 0.80 | DGAT1 (0.54) | DGAT1KDRFLT3KIT | |
| SCHEMBL178250 | 0.79 | EPHX2 (0.43) | DGAT1NAMPTKDR | |
| SCHEMBL15021905 | 0.78 | DGAT1 (0.48) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL15021989 | 0.77 | EPHX2 (0.47) | DGAT1NAMPTKDR | |
| SCHEMBL175407 | 0.77 | DGAT1 (0.47) | DGAT1CNR1NAMPTERCC5FEN1 | |
| SCHEMBL15022841 | 0.77 | DGAT1 (0.52) | DGAT1CNR1CDK5ROCK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |