Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178117 | 0.90 | EPHX2 (0.45) | EPHX2P2RY1DGAT1CA12CA1 | |
| SCHEMBL15022122 | 0.89 | EPHX2 (0.44) | EPHX2P2RY1DGAT1CA12CA1 | |
| SCHEMBL174942 | 0.89 | DGAT1 (0.48) | EPHX2DGAT1KDRNAMPT | |
| SCHEMBL176236 | 0.84 | DGAT1 (0.54) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL15021989 | 0.82 | EPHX2 (0.47) | EPHX2P2RY1DGAT1CA12CA1 | |
| SCHEMBL162613 | 0.82 | TRPV1 (0.47) | DGAT1HDAC1HDAC6TRPV1MEN1 | |
| SCHEMBL178251 | 0.80 | NTRK1 (0.45) | EPHX2P2RY1DGAT1CA12CA1 | |
| SCHEMBL15021905 | 0.80 | DGAT1 (0.48) | DGAT1KDRNAMPT | |
| SCHEMBL175408 | 0.79 | DGAT1 (0.48) | DGAT1KDRNAMPT | |
| SCHEMBL161990 | 0.78 | DGAT1 (0.51) | DGAT1MAPTNTRK1KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |