SCHEMBL17540904

SCHEMBL17540904

CCNc1ccc(C(=O)Nc2cccc3ccc(C)nc23)cc1

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 3/20 0.58
TP53 P04637 4/20 0.57
POLB P06746 4/20 0.57
MAPT P10636 5/20 0.56
GAA P10253 1/20 0.56
ALDH1A1 P00352 2/20 0.56
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
ALOX12 P18054 1/20 0.56
TSHR P16473 1/20 0.53
HSD17B10 Q99714 1/20 0.53
HDAC3 O15379 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC2 Q92769 1/20 0.48
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
THRB P10828 1/20 0.47
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26798520 0.84 MAPT (0.64) HDAC6TP53POLBMAPTGAA
SCHEMBL17552254 0.83 MAPT (0.62) HDAC6TP53POLBMAPTGAA
SCHEMBL28154257 0.83 MAPT (0.76) HDAC6TP53POLBMAPTGAA
SCHEMBL29911040 0.83 MAPT (0.56) HDAC6TP53POLBMAPTGAA
SCHEMBL22619280 0.83 MAPT (0.56) HDAC6TP53POLBMAPTGAA
SCHEMBL17540882 0.82 TDP1 (0.67) HDAC6TP53POLBMAPTGAA
SCHEMBL17552187 0.82 MAPT (0.61) HDAC6TP53POLBMAPTGAA
SCHEMBL29911126 0.82 MAPT (0.61) HDAC6TP53POLBMAPTGAA
SCHEMBL17552242 0.82 GAA (0.67) HDAC6TP53POLBMAPTGAA
SCHEMBL29911215 0.82 GAA (0.67) HDAC6TP53POLBMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2025-08-07 US disclosed
US-12144806-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2024-11-19 US disclosed
US-20240277694-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-08-22 US disclosed
US-11992487-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2024-05-28 US disclosed
EP-4037685-B9 QUINOLINE THAT MODULATE SERCA AND ITS USE FOR TREATING DISEASE NEURODON CORP (US) 2024-03-06 EP disclosed
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-01-18 US disclosed
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-01-18 US disclosed
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-01-18 US disclosed
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-11-28 US disclosed
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-11-28 US disclosed
US-20230285382-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2023-09-14 US disclosed
CN-116744928-A Quinolines modulating SERCA and their use for treating diseases 神经元公司 2023-09-12 CN disclosed
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-08-22 US disclosed
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-08-22 US disclosed
WO-2022020261-A9 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION (US) 2022-09-09 WO disclosed
US-20220016108-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2022-01-20 US disclosed
US-20200347038-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2020-11-05 US disclosed
US-20170281611-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES EIGER BIOPHARMACEUTICALS, INC. (US) 2017-10-05 US disclosed
WO-2016032569-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES CELLADON CORPORATION (US) 2016-03-03 WO disclosed
WO-2016032569-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES CELLADON CORPORATION (US) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285382-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-20170281611-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES ATP2A1, ATP2A3, ATP2A2 HDAC6 611/4885TP53 3254/4885POLB 2994/4885
US-11992487-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-12144806-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-20240277694-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-20220016108-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-20200347038-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 HDAC6 1539/4885TP53 3732/4885POLB 3166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.