ATP2A2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL38604	1.00	1/20
Thapsigargin (SCHEMBL82423)	1.00	1/20
Paxilline (SCHEMBL361232)	1.00	1/20
SCHEMBL1471247	1.00	1/20
Thapsigargin (SCHEMBL5690389)	1.00	1/20
Paxilline (SCHEMBL5955728)	1.00	1/20
Debutanoylthapsigargin (SCHEMBL2623705)	0.84	1/20
SCHEMBL67854	0.82	1/20
SCHEMBL3213952	0.78	1/20
SCHEMBL3213974	0.78	1/20
SCHEMBL6355084	0.77	1/20
SCHEMBL627857	0.75	1/20
SCHEMBL3518869	0.75	1/20
SCHEMBL5470246	0.75	1/20
SCHEMBL2623706	0.74	1/20
SCHEMBL1646372	0.72	1/20
SCHEMBL1646374	0.72	1/20
SCHEMBL3208442	0.72	1/20
SCHEMBL3208456	0.72	1/20
SCHEMBL3218093	0.72	1/20

Clinical trials — most relevant to ATP2A2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Magnesium Administration in Liver Transplantation and Reperfusion Injury	PHASE4	COMPLETED
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
Empagliflozin in Hypertrophic Cardiomyopathy	PHASE3	ACTIVE_NOT_RECRUITING
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)	PHASE3	COMPLETED
Levosimendan in Acute Decompensated Heart Failure	PHASE2/PHASE3	NOT_YET_RECRUITING
PHOspholamban RElated CArdiomyopathy STudy - Intervention	PHASE3	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction	PHASE1/PHASE2	RECRUITING
S 48168 (ARM 210) for the Treatment of RYR1-related Myopathies (RYR1-RM)	PHASE1	COMPLETED
Modulation of SERCA2a of Intra-Myocytic Calcium Trafficking in Cardiomyopathy Secondary to Duchenne Muscular Dystrophy	PHASE1	RECRUITING
Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a	EARLY_PHASE1	COMPLETED
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Calcium Handling and Epicardial Ablation	nan	COMPLETED
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Ventricular Arrhythmias in Uremic Cardiomyopathy	nan	COMPLETED
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
Carnosine Supplementation on Quantity/Quality of Oral Salivae.	nan	UNKNOWN
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
The Energetic Origin of Neurodegeneration in MS	nan	COMPLETED
Recovery From 50 Eccentric Biceps Curls in Young, Untrained Men and Women	nan	COMPLETED
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
The Prevalence of RYR1-related Disease	nan	NOT_YET_RECRUITING
Characterization of Obesity-related Cardiomyopathy Through Exploration of Human Atrial Trabeculae Contraction	nan	COMPLETED
Cardiac Contractility Modulation Therapy in Amyloid Cardiomyopathy Patients With Heart Failure	nan	UNKNOWN
Uterine Cooling During Cesarean Delivery to Reduce Blood Loss and Incidence of Postpartum Hemorrhage	nan	COMPLETED
Tart Cherry Juice for Exercise Performance and Recovery	nan	COMPLETED
A Novel Technique Of Uterine Cooling During Repeated Cesarean Section For Reducing Blood Loss	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP2A2 binder may also engage these)

Protein	Name	Similarity
P11607	—	1.000	P11607 →
P20647	—	1.000	P20647 →
Q7PPA5	—	1.000	Q7PPA5 →
O55143	—	1.000	O55143 →
P11507	—	1.000	P11507 →
Q03669	—	1.000	Q03669 →
P70083	—	1.000	P70083 →
Q64578	—	1.000	Q64578 →
Q00779	—	1.000	Q00779 →
O46674	—	1.000	O46674 →
P04191	—	1.000	P04191 →
Q8R429	—	1.000	Q8R429 →
ATP2A1	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	1.000	landscape →
P22700	—	0.999	P22700 →
P13585	—	0.999	P13585 →
Q7ZW18	—	0.999	Q7ZW18 →
P35316	—	0.999	P35316 →
Q92105	—	0.999	Q92105 →
Q0VCY0	—	0.998	Q0VCY0 →
Q292Q0	—	0.998	Q292Q0 →
Q9YGL9	—	0.997	Q9YGL9 →
Q64518	—	0.996	Q64518 →
P18596	—	0.996	P18596 →
O77696	—	0.993	O77696 →
Q9XES1	—	0.992	Q9XES1 →
ATP4A	Potassium-transporting ATPase alpha chain 1 (	0.992	landscape →
Q2RAS0	—	0.991	Q2RAS0 →
Q9SY55	—	0.991	Q9SY55 →
ATP2A3	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0.991	landscape →
O22218	—	0.991	O22218 →