Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.37 |
| ▸ | FURIN | P09958 | 2/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17550383 | 1.00 | PTPN1 (0.38) | PTPN1MDM2SIRT2SIRT1SIRT3 | |
| SCHEMBL17541309 | 0.98 | KLK7 (0.38) | PTPN1MDM2SIRT2SIRT1SIRT3 | |
| SCHEMBL29423538 | 0.94 | MDM2 (0.39) | MDM2SIRT2SIRT1SIRT3PSMB8 | |
| SCHEMBL30288542 | 0.94 | PTPN1 (0.42) | PTPN1MDM2FURINSIRT5SSTR3 | |
| SCHEMBL17550420 | 0.93 | PSMB5 (0.39) | PTPN1SIRT2SIRT1SIRT3FURIN | |
| SCHEMBL15669246 | 0.93 | FURIN (0.40) | PTPN1SIRT2SIRT1SIRT3FURIN | |
| SCHEMBL29723475 | 0.93 | FURIN (0.40) | PTPN1SIRT2SIRT1SIRT3FURIN | |
| SCHEMBL12094377 | 0.92 | HTR2A (0.40) | PTPN1SIRT2SIRT1SIRT3FURIN | |
| SCHEMBL12944195 | 0.92 | HTR2A (0.40) | PTPN1SIRT2SIRT1SIRT3FURIN | |
| SCHEMBL19731720 | 0.92 | HTR2A (0.40) | PTPN1SIRT2SIRT1SIRT3FURIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185908-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | Pfizer Inc (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016030791-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2016-03-03 | — | — | WO | disclosed |