Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 2/20 | 0.67 |
| ▸ | CA2 | P00918 | 2/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20379469 | 0.85 | NPC1 (0.78) | NPC1RAB9AKMT2AL3MBTL1GLA | |
| SCHEMBL11618998 | 0.84 | RAB9A (1.00) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL20380104 | 0.82 | L3MBTL1 (1.00) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL20379728 | 0.82 | NPC1 (0.78) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL30818065 | 0.82 | NPC1 (0.78) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL18317596 | 0.82 | RAB9A (0.80) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL3006426 | 0.81 | RAB9A (0.71) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL22103790 | 0.79 | NPC1 (1.00) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL20379320 | 0.79 | L3MBTL1 (0.74) | NPC1RAB9AKMT2AL3MBTL1CA1 | |
| SCHEMBL20379672 | 0.79 | NPC1 (0.72) | NPC1RAB9AKMT2AL3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611777-A1 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL]AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031196-A1 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |