Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544007

SCHEMBL17544007

SCHEMBL17544007

CNCc1ccc(COc2ccc3oc(-c4cccnc4)nc3c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.61
▸ KDM4E B2RXH2 13/20 0.57
▸ ALDH1A1 P00352 9/20 0.57
▸ NPC1 O15118 5/20 0.57
▸ MAPK1 P28482 1/20 0.57
▸ MAPT P10636 8/20 0.52
▸ RXFP1 Q9HBX9 1/20 0.52
▸ RAB9A P51151 5/20 0.51
▸ NPSR1 Q6W5P4 2/20 0.51
▸ CYP1A2 P05177 2/20 0.51
▸ CYP2C19 P33261 2/20 0.51
▸ HTT P42858 1/20 0.51
▸ HSD17B10 Q99714 7/20 0.48
▸ HPGD P15428 6/20 0.48
▸ POLB P06746 4/20 0.48
▸ SMN1; SMN2 Q16637 4/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ TP53 P04637 3/20 0.47
▸ USP2 O75604 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29681295 1.00 TSHR (0.61) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL17544090 0.89 TSHR (0.62) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL30403273 0.89 TSHR (0.62) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL19432714 0.89 TSHR (0.62) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL29000655 0.86 TSHR (0.62) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL30402834 0.86 TSHR (0.64) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL17544341 0.86 TSHR (0.64) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL19410514 0.86 TSHR (0.58) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL19410584 0.85 TSHR (0.57) TSHRKDM4EALDH1A1NPC1MAPK1
SCHEMBL29000642 0.84 TSHR (0.58) TSHRKDM4EALDH1A1NPC1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2022-12-29 — — US disclosed
US-11389438-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2022-07-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 TSHR 3168/4885KDM4E 4585/4885ALDH1A1 3976/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 TSHR 3537/4885KDM4E 2698/4885ALDH1A1 3950/4885
US-11389438-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 TSHR 3537/4885KDM4E 2698/4885ALDH1A1 3950/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 TSHR 3104/4885KDM4E 4674/4885ALDH1A1 3949/4885
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 TSHR 3537/4885KDM4E 2698/4885ALDH1A1 3950/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 TSHR 3168/4885KDM4E 4585/4885ALDH1A1 3976/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 TSHR 3104/4885KDM4E 4674/4885ALDH1A1 3949/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 TSHR 3168/4885KDM4E 4585/4885ALDH1A1 3976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.