SCHEMBL17544229

SCHEMBL17544229

COc1ccc(C(=O)Nc2ccc3oc(-c4ccncc4)nc3c2)cc1

nearest known ligand 0.88

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 15/20 0.88
THRB P10828 2/20 0.88
TP53 P04637 1/20 0.77
KDM4E B2RXH2 6/20 0.75
ALDH1A1 P00352 4/20 0.75
SMN1; SMN2 Q16637 2/20 0.75
APEX1 P27695 1/20 0.75
TDP1 Q9NUW8 1/20 0.75
NPSR1 Q6W5P4 2/20 0.74
RXFP1 Q9HBX9 2/20 0.74
PTGS2 P35354 1/20 0.74
POLB P06746 3/20 0.73
TSHR P16473 2/20 0.71
LMNA P02545 1/20 0.71
MAPK1 P28482 1/20 0.71
HPGD P15428 1/20 0.67
PPARG P37231 1/20 0.67
NCOA2 Q15596 1/20 0.67
NCOA1 Q15788 1/20 0.67
HSD17B10 Q99714 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30402400 1.00 MAPT (0.88) MAPTTHRBTP53KDM4EALDH1A1
SCHEMBL2242480 0.96 MAPT (0.88) MAPTTHRBTP53KDM4EALDH1A1
SCHEMBL2244624 0.93 MAPT (1.00) MAPTTHRBTP53RXFP1PTGS2
SCHEMBL30402949 0.93 MAPT (1.00) MAPTTHRBTP53RXFP1PTGS2
SCHEMBL2247470 0.90 MAPT (0.89) MAPTTHRBTP53KDM4EALDH1A1
SCHEMBL16217094 0.89 MAPT (0.92) MAPTTHRBTP53RXFP1PTGS2
SCHEMBL2244186 0.89 MAPT (0.92) MAPTTHRBTP53RXFP1PTGS2
SCHEMBL2248135 0.88 MAPT (0.90) MAPTTHRBTP53SMN1; SMN2RXFP1
SCHEMBL2243688 0.88 MAPT (1.00) MAPTTHRBTP53KDM4EALDH1A1
SCHEMBL30403230 0.88 MAPT (1.00) MAPTTHRBTP53KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 CN disclosed
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 MAPT 8/4885THRB 2552/4885TP53 741/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 MAPT 12/4885THRB 2721/4885TP53 42/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 MAPT 7/4885THRB 2432/4885TP53 743/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 MAPT 8/4885THRB 2552/4885TP53 741/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 MAPT 7/4885THRB 2432/4885TP53 743/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 MAPT 8/4885THRB 2552/4885TP53 741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.