Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 8/20 | 0.56 |
| ▸ | NOS3 | P29474 | 7/20 | 0.56 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22791916 | 0.85 | NOS2 (0.54) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL30039026 | 0.80 | NOS2 (0.52) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL790700 | 0.80 | NOS2 (0.52) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL23030535 | 0.79 | NOS2 (0.42) | NOS2NOS3NOS1KDM4EMEN1 | |
| SCHEMBL6947890 | 0.79 | NOS3 (0.47) | NOS2NOS3NOS1 | |
| SCHEMBL10222482 | 0.77 | CYP2A6 (0.35) | NOS2NOS3 | |
| SCHEMBL20010424 | 0.77 | NOS2 (0.39) | NOS2NOS3NOS1P2RX3P2RX2 | |
| SCHEMBL18609308 | 0.77 | NOS2 (0.39) | NOS2NOS3NOS1P2RX3P2RX2 | |
| SCHEMBL10105612 | 0.76 | NOS3 (0.32) | NOS2NOS3 | |
| SCHEMBL24287969 | 0.76 | TAAR1 (0.37) | NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242551-A1 | ISOTOPE-SUBSTITUTED SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2023-08-03 | — | — | US | disclosed |
| US-11701354-B2 | Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors | D. E. SHAW RESEARCH, LLC (US) | 2023-07-18 | — | — | US | disclosed |
| US-11701354-B2 | Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors | D. E. SHAW RESEARCH, LLC (US) | 2023-07-18 | — | — | US | disclosed |
| US-11529348-B2 | — | — | 2022-12-20 | — | — | US | disclosed |
| US-20200253969-A1 | PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS | SCHRODINGER, LLC | 2020-08-13 | — | — | US | disclosed |
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| WO-2018057810-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-29 | — | — | WO | disclosed |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| US-20170027956-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. | 2017-02-02 | — | — | US | disclosed |
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11529348-B2 | — | PTPRCAP, PTPN2, PTPN6 | NOS2 2466/4885NOS3 2972/4885NOS1 3064/4885 |
| US-20230242551-A1 | ISOTOPE-SUBSTITUTED SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF | SLCO1B1, SLCO1B3, SLCO2B1 | NOS2 4086/4885NOS3 3832/4885NOS1 3869/4885 |
| US-10227350-B2 | Phosphatidylinositol 3-kinase inhibitors | PIK3CA, AKT3, AKT1 | NOS2 3309/4885NOS3 1735/4885NOS1 2453/4885 |
| US-20170027956-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | TEC, ABL1, LCK | NOS2 3507/4885NOS3 3275/4885NOS1 3420/4885 |
| US-20180086768-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, AKT1 | NOS2 3309/4885NOS3 1735/4885NOS1 2453/4885 |
| US-11701354-B2 | Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors | PTPN5, PTPN2, PTPN7 | NOS2 2730/4885NOS3 2399/4885NOS1 3094/4885 |
| US-20200253969-A1 | PYRAZOLO[3,4-B]PYRAZINE DERIVATIVES AS SHP2 PHOSPHATASE INHIBITORS | PTPN5, PTPN2, PPM1A | NOS2 2201/4885NOS3 1811/4885NOS1 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.