Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.32 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.32 |
| ▸ | RPS17 | P08708 | 1/20 | 0.32 |
| ▸ | RPSA | P08865 | 1/20 | 0.32 |
| ▸ | RPS2 | P15880 | 1/20 | 0.32 |
| ▸ | RPL35A | P18077 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729078 | 0.90 | JAK2 (0.37) | ALDH1A1TP53L3MBTL1ALOX15MAPK1 | |
| SCHEMBL17545892 | 0.90 | JAK2 (0.37) | ALDH1A1TP53L3MBTL1ALOX15MAPK1 | |
| SCHEMBL17545901 | 0.89 | TP53 (0.46) | TP53L3MBTL1CHEK1KCNH2HTR6 | |
| SCHEMBL6128820 | 0.89 | TP53 (0.46) | TP53L3MBTL1CHEK1KCNH2HTR6 | |
| SCHEMBL17545911 | 0.88 | TP53 (0.39) | TP53L3MBTL1CHEK1KCNH2HTR6 | |
| SCHEMBL6128817 | 0.88 | TP53 (0.39) | TP53L3MBTL1CHEK1KCNH2HTR6 | |
| SCHEMBL6128888 | 0.87 | CHEK1 (0.40) | TP53L3MBTL1CHEK1KCNH2HTR6 | |
| SCHEMBL17545897 | 0.86 | L3MBTL1 (0.42) | ALDH1A1POLBTP53L3MBTL1ALOX15 | |
| SCHEMBL1531533 | 0.83 | RPLP1 (0.40) | L3MBTL1KCNH2HTR6JAK2JAK1 | |
| SCHEMBL17545924 | 0.83 | HTR6 (0.37) | ALDH1A1POLBTP53L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170027956-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. | 2017-02-02 | — | — | US | disclosed |
| US-20170027956-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | BIOGEN IDEC MA INC. | 2017-02-02 | — | — | US | disclosed |
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273028-B2 | Heterocyclic tyrosine kinase inhibitors | BIOGEN MA INC. (US) | 2016-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170027956-A1 | HETEROCYCLIC TYROSINE KINASE INHIBITORS | TEC, ABL1, LCK | ALDH1A1 3902/4885POLB 3612/4885MAPT 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.