SCHEMBL17548442

SCHEMBL17548442

Cc1ccc2c(C(C[N+](=O)[O-])c3cccs3)c(-c3ccccc3)[nH]c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 18/20 1.00
MEN1 O00255 2/20 0.66
MAPT P10636 2/20 0.66
KMT2A Q03164 2/20 0.66
NPSR1 Q6W5P4 2/20 0.66
LMNA P02545 1/20 0.66
ATM Q13315 1/20 0.66
CNR2 P34972 1/20 0.55
KDM4E B2RXH2 1/20 0.54
ALDH1A1 P00352 1/20 0.54
GAA P10253 1/20 0.54
HTT P42858 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31282971 1.00 CNR1 (1.00) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL31282350 0.91 CNR1 (0.82) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL17548550 0.88 CNR1 (1.00) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL31282921 0.88 CNR1 (0.78) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL31282892 0.86 CNR1 (0.76) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL31282339 0.86 CNR1 (0.75) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL31282574 0.85 CNR1 (0.74) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL17548474 0.85 CNR1 (0.79) CNR1CNR2
SCHEMBL31282426 0.83 CNR1 (0.70) CNR1MEN1MAPTKMT2ANPSR1
SCHEMBL31283302 0.83 CNR1 (0.70) CNR1MEN1MAPTKMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4486336-A2 CB1 LIGAND CONJUGATED COMPOUNDS AND USES THEREOF Adarx Pharmaceuticals, Inc. (US) 2025-01-08 EP claimed
CN-119136797-A CB1Ligand conjugated compounds and uses thereof 阿达尔克斯制药有限公司 2024-12-13 CN claimed
US-20240408059-A1 METHOD OF TREATING ADDICTION ANEBULO PHARMACEUTICALS, INC. 2024-12-12 US claimed
WO-2023168296-A2 CB1 LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2023-09-07 WO claimed
WO-2023064228-A1 METHOD OF TREATING ADDICTION ANEBULO PHARMACEUTICALS, INC. (US) 2023-04-20 WO claimed
US-20260115176-A1 ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS AND METHODS OF TREATING NEUROPATHIC PAIN UNIV LELAND STANFORD JUNIOR (US) 2026-04-30 US disclosed
EP-4486336-A2 CB1 LIGAND CONJUGATED COMPOUNDS AND USES THEREOF Adarx Pharmaceuticals, Inc. (US) 2025-01-08 EP disclosed
WO-2024263969-A2 HETEROARYL COMPOUNDS AS ENDOCANNABINOID SYSTEM MODULATORS AND USES THEREOF NORTHEASTERN UNIVERSITY (US) 2024-12-26 WO disclosed
CN-119136797-A CB1Ligand conjugated compounds and uses thereof 阿达尔克斯制药有限公司 2024-12-13 CN disclosed
US-20240408059-A1 METHOD OF TREATING ADDICTION ANEBULO PHARMACEUTICALS, INC. 2024-12-12 US disclosed
WO-2024112721-A1 ALLOSTERIC MODULATORS OF THE μ-OPIOID RECEPTOR AND CANNABINOID RECEPTOR 1 CZ BIOHUB SF, LLC (US) 2024-05-30 WO disclosed
CN-117717546-A Application of indole derivatives in preparation of medicines for preventing and/or treating pain 四川大学华西医院 2024-03-19 CN disclosed
WO-2023064228-A1 METHOD OF TREATING ADDICTION ANEBULO PHARMACEUTICALS, INC. (US) 2023-04-20 WO disclosed
US-20230047251-A1 ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS AND METHODS OF TREATING NEUROPATHIC PAIN THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2023-02-16 US disclosed
US-11084781-B2 Diarylureas as CB1 allosteric modulators RESEARCH TRIANGLE INSTITUTE (US) 2021-08-10 US disclosed
US-20200062699-A1 DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2020-02-27 US disclosed
US-10377711-B2 Cannabinoid type 1 receptor modulators THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2019-08-13 US disclosed
US-20180118681-A1 CANNABINOID TYPE 1 RECEPTOR MODULATORS THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2018-05-03 US disclosed
US-20180118681-A1 CANNABINOID TYPE 1 RECEPTOR MODULATORS THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN (GB) 2018-05-03 US disclosed
WO-2016029310-A1 CANNABINOID TYPE 1 RECEPTOR MODULATORS THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115176-A1 ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS AND METHODS OF TREATING NEUROPATHIC PAIN CNR1, CNR2, OPRL1 CNR1 1/4885MEN1 4792/4885MAPT 3434/4885
US-20240408059-A1 METHOD OF TREATING ADDICTION CNR2, CNR1, OPRM1 CNR1 2/4885MEN1 4073/4885MAPT 792/4885
US-20180118681-A1 CANNABINOID TYPE 1 RECEPTOR MODULATORS CNR1, CNR2, GPR18 CNR1 1/4885MEN1 3818/4885MAPT 2186/4885
US-11084781-B2 Diarylureas as CB1 allosteric modulators CNR1, CNR2, GPR18 CNR1 1/4885MEN1 3226/4885MAPT 2523/4885
US-20200062699-A1 DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS CNR1, CNR2, GPR18 CNR1 1/4885MEN1 3226/4885MAPT 2523/4885
US-10377711-B2 Cannabinoid type 1 receptor modulators CNR1, CNR2, GPR18 CNR1 1/4885MEN1 3818/4885MAPT 2186/4885
US-20230047251-A1 ALLOSTERIC MODULATORS OF CANNABINOID RECEPTORS AND METHODS OF TREATING NEUROPATHIC PAIN CNR1, CNR2, TRPV1 CNR1 1/4885MEN1 4792/4885MAPT 869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.