⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13620726 | 0.62 | — | — | |
| SCHEMBL20267202 | 0.57 | — | — | |
| SCHEMBL2048133 | 0.54 | — | — | |
| SCHEMBL7068841 | 0.54 | — | — | |
| SCHEMBL1145502 | 0.51 | — | — | |
| SCHEMBL8265788 | 0.49 | CYP3A4 (0.35) | — | |
| SCHEMBL353814 | 0.45 | NNMT (0.54) | — | |
| SCHEMBL1276533 | 0.41 | CYP3A4 (0.59) | — | |
| 1,4-Dimethoxybenzene SCHEMBL21802643 | 0.41 | CA1 (1.00) | — | |
| 1,4-Dimethoxybenzene SCHEMBL8489 | 0.41 | CA1 (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160362392-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2016-12-15 | — | — | US | disclosed |
| US-9452999-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2016-09-27 | — | — | US | disclosed |
| EP-2343069-B1 | Heterocyclic aspartyl protease inhibitors | MERCK SHARP & DOHME (US) | 2016-03-02 | — | — | EP | disclosed |
| US-20150266859-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2015-09-24 | — | — | US | disclosed |
| US-9073871-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140371467-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2014-12-18 | — | — | US | disclosed |
| US-8859591-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130296355-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER (US) | 2013-11-07 | — | — | US | disclosed |
| US-8507533-B2 | Glucagon receptor modulators | PFIZER INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120202834-A1 | GLUCAGON RECEPTOR MODULATORS | PFIZER INC. (US) | 2012-08-09 | — | — | US | disclosed |