Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QRFPR | Q96P65 | 13/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116750 | 0.89 | ROCK2 (0.46) | CYP2D6ROCK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL118962 | 0.89 | ROCK2 (0.45) | CYP2D6ROCK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL118485 | 0.88 | ROCK2 (0.46) | CYP2D6ROCK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL116962 | 0.84 | QRFPR (0.77) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL566537 | 0.82 | ROCK2 (0.44) | ROCK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL117808 | 0.79 | QRFPR (0.63) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL117974 | 0.78 | QRFPR (0.68) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL119128 | 0.77 | QRFPR (0.58) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL566626 | 0.77 | ROCK2 (0.59) | ROCK2MEN1KMT2AL3MBTL1 | |
| SCHEMBL118024 | 0.76 | QRFPR (0.56) | QRFPRKCNH2CYP2D6KCNE1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424861-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | claimed |
| WO-2010126164-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | claimed |