Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QRFPR | Q96P65 | 10/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119128 | 0.90 | QRFPR (0.58) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL117974 | 0.84 | QRFPR (0.68) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL116962 | 0.84 | QRFPR (0.77) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL118802 | 0.83 | QRFPR (0.59) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL116600 | 0.83 | QRFPR (0.59) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL118302 | 0.81 | QRFPR (0.51) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL117808 | 0.80 | QRFPR (0.63) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL565379 | 0.78 | QRFPR (0.76) | QRFPRKCNH2CYP2D6KCNE1SCN5A | |
| SCHEMBL566626 | 0.77 | ROCK2 (0.59) | HPGDMAPTKDM4EHDAC1TP53 | |
| SCHEMBL117608 | 0.77 | ROCK2 (0.48) | HPGDMAPTKDM4EHDAC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424861-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | MSD K.K. (JP) | 2012-02-09 | — | — | US | disclosed |
| WO-2010126164-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | HTR1F, HTR3C, HTR6 | QRFPR 11/4885KCNH2 829/4885CYP2D6 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.