SCHEMBL17552189

SCHEMBL17552189

Cc1ccc2cccc(NC(=O)c3ccccc3Cl)c2n1

nearest known ligand 0.74

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.74
GAA P10253 1/20 0.74
KDR P35968 1/20 0.68
TP53 P04637 4/20 0.65
THRB P10828 2/20 0.61
CYP1A2 P05177 1/20 0.57
HPGD P15428 1/20 0.57
CYP2C19 P33261 1/20 0.57
ALDH1A1 P00352 2/20 0.56
TSHR P16473 1/20 0.56
HSD17B10 Q99714 1/20 0.56
MEN1 O00255 1/20 0.56
ALOX12 P18054 1/20 0.56
KMT2A Q03164 1/20 0.56
POLB P06746 1/20 0.54
RAB9A P51151 2/20 0.52
NPC1 O15118 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29911131 1.00 MAPT (0.74) MAPTGAAKDRTP53THRB
SCHEMBL6537844 0.86 MAPT (0.62) MAPTGAAKDRTP53THRB
SCHEMBL26798492 0.86 MAPT (0.78) MAPTGAAKDRTP53THRB
SCHEMBL29911123 0.86 MAPT (0.62) MAPTGAAKDRTP53THRB
SCHEMBL17552233 0.86 MAPT (0.62) MAPTGAAKDRTP53THRB
SCHEMBL29911019 0.84 MAPT (0.74) MAPTGAAKDRTP53THRB
SCHEMBL17552194 0.84 MAPT (0.74) MAPTGAAKDRTP53THRB
SCHEMBL29831357 0.82 MAPT (0.71) MAPTGAAKDRTP53THRB
SCHEMBL29911133 0.82 TP53 (0.77) MAPTGAATP53THRBALDH1A1
SCHEMBL17552229 0.82 TP53 (0.77) MAPTGAATP53THRBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-01-18 US disclosed
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-11-28 US disclosed
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-11-28 US disclosed
EP-4037685-B1 QUINOLINE THAT MODULATE SERCA AND ITS USE FOR TREATING DISEASE NEURODON CORP (US) 2023-09-20 EP disclosed
US-20230285382-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2023-09-14 US disclosed
CN-116744928-A Quinolines modulating SERCA and their use for treating diseases 神经元公司 2023-09-12 CN disclosed
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-08-22 US disclosed
US-20220016108-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2022-01-20 US disclosed
US-20200347038-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2020-11-05 US disclosed
US-10772881-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION 2020-09-15 US disclosed
US-20190151303-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2019-05-23 US disclosed
US-20170281611-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES EIGER BIOPHARMACEUTICALS, INC. (US) 2017-10-05 US disclosed
WO-2016032569-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES CELLADON CORPORATION (US) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285382-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885KDR 4506/4885
US-20170281611-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES ATP2A1, ATP2A3, ATP2A2 MAPT 1538/4885GAA 36/4885KDR 4844/4885
US-10772881-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1307/4885GAA 65/4885KDR 4683/4885
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885KDR 4506/4885
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885KDR 4506/4885
US-20190151303-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1307/4885GAA 65/4885KDR 4683/4885
US-20220016108-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885KDR 4506/4885
US-20200347038-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885KDR 4506/4885
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885KDR 4506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.