Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 13/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755315 | 0.82 | LMNA (0.39) | LMNAHTTSMN1; SMN2EGFRHDAC3 | |
| SCHEMBL1755314 | 0.82 | EGFR (0.49) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10231682 | 0.81 | LMNA (0.32) | LMNAHTTSMN1; SMN2EGFRHDAC3 | |
| SCHEMBL1707561 | 0.79 | HDAC3 (0.51) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1707502 | 0.77 | EGFR (0.38) | EGFRHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13784505 | 0.75 | ABCG2 (0.38) | LMNAHTTSMN1; SMN2EGFRHDAC3 | |
| SCHEMBL1755322 | 0.75 | LMNA (0.47) | LMNAHTTSMN1; SMN2EGFRKRAS | |
| SCHEMBL1706654 | 0.65 | HTT (0.46) | LMNAHTTSMN1; SMN2EGFRERBB2 | |
| SCHEMBL1841173 | 0.64 | HTT (0.45) | LMNAHTTSMN1; SMN2EGFRKRAS | |
| SCHEMBL1839570 | 0.64 | EGFR (0.51) | LMNAHTTEGFRKRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247579-B1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | Bayer Pharma AG (DE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2009089851-A1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-23 | — | — | WO | disclosed |