Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CD38 | P28907 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 8/20 | 0.36 |
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755315 | 0.78 | LMNA (0.39) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL1708258 | 0.75 | LMNA (0.61) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL1755296 | 0.75 | LMNA (0.36) | LMNAHTTSMN1; SMN2EGFRKRAS | |
| SCHEMBL1706562 | 0.73 | LMNA (0.51) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL1707249 | 0.73 | EGFR (0.58) | LMNAHTTSMN1; SMN2EGFRKRAS | |
| SCHEMBL1708313 | 0.72 | LMNA (0.54) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL12935442 | 0.72 | LMNA (0.50) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL1707037 | 0.72 | LMNA (0.50) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL1707023 | 0.69 | HTT (0.56) | LMNAHTTSMN1; SMN2CD38EGFR | |
| SCHEMBL27409854 | 0.68 | LMNA (0.59) | LMNAHTTSMN1; SMN2CD38EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247579-B1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | Bayer Pharma AG (DE) | 2012-04-18 | — | — | EP | disclosed |
| WO-2009089851-A1 | SULPHOXIMINE-SUBSTITUTED QUINAZOLINE DERIVATIVES AS IMMUNOMODULATORS, THEIR PREPARATION AND USE AS MEDICAMENTS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-23 | — | — | WO | disclosed |