Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 0.78 |
| ▸ | POLB | P06746 | 3/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | ATM | Q13315 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187363 | 0.87 | TSHR (0.71) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL14976726 | 0.84 | TSHR (1.00) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL4474896 | 0.84 | TSHR (0.67) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL3756685 | 0.82 | POLB (0.68) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL19610261 | 0.81 | KDM1A (0.61) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL7516710 | 0.81 | MAPT (0.76) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL14434545 | 0.80 | TSHR (0.67) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL24187366 | 0.78 | KDM4E (0.60) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL17560051 | 0.77 | TSHR (0.52) | TSHRPOLBHSD17B10KDM4EMAPT | |
| SCHEMBL22442068 | 0.75 | KDM1A (0.58) | TSHRPOLBHSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3668877-B1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2024-05-01 | — | — | EP | disclosed |
| EP-3189059-B1 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2023-02-22 | — | — | EP | disclosed |
| US-10980777-B2 | Indole derivatives as histone demethylase inhibitors | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2021-04-20 | — | — | US | disclosed |
| US-20200289463-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2020-09-17 | — | — | US | disclosed |
| EP-3668877-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034774-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA (IEO) S.R.L. (IT) | 2019-02-21 | — | — | WO | disclosed |
| US-10183952-B2 | Thienopyrroles as histone demethylase inhibitors | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2019-01-22 | — | — | US | disclosed |
| US-20170260197-A1 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-09-14 | — | — | US | disclosed |
| EP-3189059-A2 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2017-07-12 | — | — | EP | disclosed |
| WO-2016034946-A2 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-03-10 | — | — | WO | disclosed |
| EP-2993175-A1 | Thienopyrroles as histone demethylase inhibitors | IEO - Istituto Europeo di Oncologia Srl (IT) | 2016-03-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980777-B2 | Indole derivatives as histone demethylase inhibitors | KDM1B, KDM1A, INMT | TSHR 1249/4885POLB 1952/4885HSD17B10 747/4885 |
| US-20200289463-A1 | INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, INMT | TSHR 1249/4885POLB 1952/4885HSD17B10 747/4885 |
| US-10183952-B2 | Thienopyrroles as histone demethylase inhibitors | KDM1A, KDM1B, KDM3A | TSHR 1132/4885POLB 2606/4885HSD17B10 408/4885 |
| US-20170260197-A1 | THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS | KDM1A, KDM1B, KDM3A | TSHR 1132/4885POLB 2606/4885HSD17B10 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.