Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17554664 | 0.92 | ULK1 (0.37) | ULK1PTK2NEK2KDRFLT4 | |
| SCHEMBL670806 | 0.83 | ULK1 (0.45) | ULK1PTK2NEK2KDR | |
| SCHEMBL15033827 | 0.81 | ULK1 (0.56) | ULK1PTK2KIF11 | |
| SCHEMBL669223 | 0.76 | ULK1 (0.40) | ULK1PTK2NEK2 | |
| SCHEMBL17554666 | 0.76 | ULK1 (0.49) | ULK1NEK2KDRMAOAMAOB | |
| SCHEMBL15033846 | 0.75 | ULK1 (0.56) | ULK1PTK2KIF11 | |
| SCHEMBL15033850 | 0.75 | PTK2B (0.52) | ULK1PTK2KDR | |
| SCHEMBL15033841 | 0.74 | ULK1 (0.54) | ULK1PTK2 | |
| SCHEMBL669259 | 0.74 | ULK1 (0.43) | ULK1PTK2NEK2KDRFLT4 | |
| SCHEMBL15033857 | 0.73 | ULK1 (0.71) | ULK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606034-B1 | PYRIMIDINE DERIVATIVE AS FAK INHIBITORS | MERCK PATENT GMBH (DE) | 2016-03-09 | — | — | EP | disclosed |