Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 9/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 9/20 | 0.36 |
| ▸ | BIRC3 | Q13489 | 4/20 | 0.36 |
| ▸ | BUB1 | O43683 | 2/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTR1E | P28566 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2622149 | 0.91 | HSD17B10 (0.39) | CTSLCTSSCTSKTSHRUSP30 | |
| SCHEMBL2117031 | 0.91 | HSD17B10 (0.39) | CTSLCTSSCTSKTSHRUSP30 | |
| SCHEMBL10284064 | 0.85 | BUB1 (0.37) | XIAPBIRC2BIRC3BUB1CTSV | |
| SCHEMBL2113024 | 0.85 | BUB1 (0.37) | XIAPBIRC2BIRC3BUB1CTSV | |
| SCHEMBL13048815 | 0.83 | CTSL (0.39) | CTSLCTSSCTSKMEN1MAPT | |
| SCHEMBL2113432 | 0.82 | CTSL (0.40) | XIAPBIRC2BIRC3CTSLCTSS | |
| SCHEMBL2622097 | 0.82 | CTSL (0.40) | XIAPBIRC2BIRC3CTSLCTSS | |
| SCHEMBL17577847 | 0.78 | CTSL (0.38) | CTSLCTSSCTSK | |
| SCHEMBL2622099 | 0.78 | — | — | |
| SCHEMBL2113969 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2434889-B1 | IAP INHIBITORS | TETRALOGIC BIRINAPANT UK LTD (GB) | 2016-03-09 | — | — | EP | disclosed |