Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487256 | 0.86 | — | — | |
| SCHEMBL7486373 | 0.84 | — | — | |
| SCHEMBL2283357 | 0.79 | — | — | |
| SCHEMBL4560663 | 0.79 | — | — | |
| SCHEMBL2467227 | 0.77 | — | — | |
| SCHEMBL4618922 | 0.77 | — | — | |
| SCHEMBL31385 | 0.77 | — | — | |
| SCHEMBL700524 | 0.77 | — | — | |
| SCHEMBL8777745 | 0.77 | — | — | |
| SCHEMBL11125397 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8604200-B2 | Diaza-spiro-{4,4}-nonane derivatives as neurokinin (NK1) antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-12-10 | — | — | US | claimed |
| US-8138334-B2 | Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-03-20 | — | — | US | claimed |
| JP-4746878-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| JP-4662777-B2 | — | — | 2011-03-30 | — | — | JP | claimed |
| EP-1581518-B1 | SUBSTITUTED 1-PIPERIDIN-4-YL-4-PYRROLIDIN-3-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-02 | — | — | EP | claimed |
| US-20100292228-A1 | SUBSTITUTED OXA-DIAZA-SPIRO-[5.5]-UNDECANONE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-18 | — | — | US | claimed |
| US-7795261-B2 | Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-14 | — | — | US | claimed |
| EP-1578423-B1 | 2-AMINOCARBONYL-QUINOLINE COMPOUNDS AS PLATELET ADENOSINE DIPHOSPHATE RECEPTOR ANTAGONISTS | BAYER SCHERING PHARMA AG (DE) | 2010-08-18 | — | — | EP | claimed |
| EP-1858896-B1 | DIAZA-SPIRO-[4.4]-NONANE DERIVATIVES AS NEUROKININ (NK1) ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-18 | — | — | EP | claimed |
| EP-1874783-B1 | SUBSTITUTED OXA-DIAZA-SPIRO-[5.5]-UNDECANONE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-26 | — | — | EP | claimed |
| WO-1999029677-A1 | SUBSTITUTED 2,4-DIAMINO-1,3,5-TRIAZINES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-06-17 | — | — | WO | claimed |
| WO-1999021841-A1 | SUBSTITUTED ARYLOXY ALKYL AMINO TRIAZINES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-05-06 | — | — | WO | claimed |
| WO-1999012913-A1 | SUBSTITUTED PHENYLURACILS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-03-18 | — | — | WO | claimed |
| WO-1995022586-A1 | NEW POLYMERISABLE LIQUID CRYSTAL COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 1995-08-24 | — | — | WO | claimed |
| EP-0410238-A2 | Pyridazinone derivatives | BAYER AG (DE) | 1991-01-30 | — | — | EP | claimed |
| US-4906286-A | Herbicidal 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs thereof | FMC CORPORATION (US) | 1990-03-06 | — | — | US | claimed |
| EP-0185731-A4 | HERBICIDAL 2-ARYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES AND SULFUR ANALOGS THEREOF. | FMC CORP (US) | 1988-11-02 | — | — | EP | claimed |
| US-4766233-A | Herbicidal 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs thereof | FMC CORPORATION (US) | 1988-08-23 | — | — | US | claimed |
| EP-0185731-A1 | HERBICIDAL 2-ARYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES AND SULFUR ANALOGS THEREOF | FMC Corporation (US) | 1986-07-02 | — | — | EP | claimed |
| WO-1986000072-A1 | HERBICIDAL 2-ARYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONES AND SULFUR ANALOGS THEREOF | FMC CORPORATION (US) | 1986-01-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292228-A1 | SUBSTITUTED OXA-DIAZA-SPIRO-[5.5]-UNDECANONE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | NPSR1, OPRK1, PROKR2 | TSHR 2386/4885LMNA 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.