Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 10/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755709 | 0.89 | MAPT (0.41) | CYSLTR1CYSLTR2MAPTCYP2C9CYP2C19 | |
| SCHEMBL1755775 | 0.89 | MAPT (0.41) | CYSLTR1CYSLTR2MAPTCYP2C9CYP2C19 | |
| SCHEMBL1755713 | 0.88 | MAPT (0.40) | CYSLTR1CYSLTR2MAPTCYP2C9CYP2C19 | |
| SCHEMBL10247574 | 0.86 | GRM2 (0.42) | CYSLTR1MAPTCYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL8263462 | 0.86 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2MAPTGRM2PDE5A | |
| SCHEMBL1755741 | 0.83 | MAPT (0.37) | CYSLTR1CYSLTR2MAPTCYP2C9CYP2C19 | |
| Ly-2300559 SCHEMBL481118 | 0.81 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2MAPTGRM2PDE5A | |
| Ly-2300559 SCHEMBL480820 | 0.81 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2MAPTGRM2PDE5A | |
| Ly-2300559 SCHEMBL8264028 | 0.81 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2MAPTGRM2PDE5A | |
| Ly-2300559 SCHEMBL481075 | 0.80 | CYSLTR1 (0.58) | CYSLTR1CYSLTR2MAPTGRM2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441762-A1 | Potentiators of Glutamate Receptors | Eli Lilly and Company (US) | 2012-04-18 | — | — | EP | disclosed |