Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 9/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755964 | 0.80 | ALK (0.47) | ALK | |
| SCHEMBL20855586 | 0.67 | AR (0.50) | — | |
| SCHEMBL30468153 | 0.67 | AR (0.50) | — | |
| SCHEMBL7291041 | 0.67 | AR (0.46) | LRRK2 | |
| SCHEMBL897695 | 0.65 | ALK (0.73) | ALK | |
| SCHEMBL23676452 | 0.65 | IMPDH2 (0.38) | ALK | |
| SCHEMBL23676490 | 0.64 | RET (0.39) | ALK | |
| SCHEMBL3361866 | 0.63 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL29149145 | 0.61 | KMT2A (0.44) | — | |
| SCHEMBL4878704 | 0.61 | GPR17 (0.49) | TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |