Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.47 |
| ▸ | FASN | P49327 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755801 | 0.80 | CFB (0.40) | ALK | |
| SCHEMBL897625 | 0.70 | ALK (0.73) | ALK | |
| SCHEMBL20004106 | 0.69 | ALK (0.51) | ALKFASNKCNH2 | |
| SCHEMBL17048315 | 0.67 | ALK (0.54) | ALK | |
| SCHEMBL17048116 | 0.66 | ALK (0.41) | ALKHRH3 | |
| SCHEMBL17048360 | 0.65 | ALK (0.95) | ALK | |
| SCHEMBL17048359 | 0.64 | ALK (1.00) | ALK | |
| SCHEMBL18589164 | 0.62 | ALK (0.45) | ALKHRH3 | |
| SCHEMBL6715062 | 0.61 | PANK3 (0.56) | — | |
| SCHEMBL17048161 | 0.60 | ALK (0.66) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |