Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.44 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.44 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983344 | 0.88 | GLA (0.59) | GLATSHREPHX2EPHX1LMNA | |
| SCHEMBL23673611 | 0.86 | GLA (0.46) | GLATSHRTPSAB1TPSD1TPSG1 | |
| SCHEMBL999224 | 0.85 | TPSAB1 (0.50) | GLATPSAB1TPSD1TPSG1GAA | |
| Hydrochloric Acid SCHEMBL999223 | 0.83 | TPSAB1 (0.49) | GLATPSAB1TPSD1TPSG1POLB | |
| SCHEMBL14905948 | 0.82 | TSHR (0.66) | TSHRTPSAB1TPSD1TPSG1LMNA | |
| SCHEMBL25773746 | 0.82 | TSHR (0.45) | GLATSHRTPSAB1TPSD1TPSG1 | |
| Dimethyl Succinate SCHEMBL27941260 | 0.82 | TSHR (0.72) | GLATSHRLMNAPOLBMAPT | |
| SCHEMBL12259096 | 0.81 | GLA (0.54) | GLATSHREPHX2EPHX1LMNA | |
| SCHEMBL17576885 | 0.81 | GLA (0.54) | GLATSHREPHX2EPHX1LMNA | |
| Hydrochloric Acid SCHEMBL15987604 | 0.81 | TSHR (0.64) | TSHRTPSAB1TPSD1TPSG1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117229215-A | Biaryl compound, pharmaceutical composition containing biaryl compound, preparation method and application of biaryl compound | 四川科伦博泰生物医药股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-114096525-B | Biaryl compound, pharmaceutical composition containing biaryl compound, preparation method and application of biaryl compound | 四川科伦博泰生物医药股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-114096525-A | Biaryl compounds, pharmaceutical compositions containing them, processes for their preparation and their use | 四川科伦博泰生物医药股份有限公司 | 2022-02-25 | — | — | CN | disclosed |
| WO-2021047407-A1 | BIARYL COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-03-18 | — | — | WO | disclosed |
| US-9980967-B1 | Method for overcoming drug resistance of EGFR mutation and cancerous stemness of human non-small cell lung carcinoma | NATIONAL CHIAO TUNG UNIVERSITY (TW) | 2018-05-29 | — | — | US | disclosed |
| US-9980967-B1 | Method for overcoming drug resistance of EGFR mutation and cancerous stemness of human non-small cell lung carcinoma | NATIONAL CHIAO TUNG UNIVERSITY (TW) | 2018-05-29 | — | — | US | disclosed |
| US-9512086-B2 | Compound for promoting apoptosis of cancer cells and a pharmaceutical composition containing the same and uses thereof | NATIONAL CHIAO TUNG UNIVERSITY (TW) | 2016-12-06 | — | — | US | disclosed |
| US-20160068495-A1 | COMPOUND FOR PROMOTING APOPTOSIS OF CANCER CELLS AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USES THEREOF | NATIONAL CHIAO TUNG UNIVERSITY (TW) | 2016-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068495-A1 | COMPOUND FOR PROMOTING APOPTOSIS OF CANCER CELLS AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USES THEREOF | BAX, BCL2, CASP3 | GLA 4516/4885TSHR 4780/4885TPSAB1 3781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.